Replication errors: cha(lle)nging the genome
نویسندگان
چکیده
منابع مشابه
Replication errors: cha(lle)nging the genome.
Since the discovery of a link between the malfunction of post-replicative mismatch correction and hereditary non-polyposis colon cancer, the study of this complex repair pathway has received a great deal of attention. Our understanding of the mammalian system was facilitated by conservation of the main protagonists of this process from microbes to humans. Thus, biochemical experiments carried o...
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A t the time that Watson and Crick proposed a structure for DNA, a visionary might have suggested that the complete genetic sequence of an organism would eventually be known. However, nobody could have realistically proposed that machines could automatically indicate gene functions. Yet precisely this has been achieved: with no laboratory experiments at all, the roles of most genes in several o...
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The replication of DNA is initiated at particular sites on the genome called replication origins (ROs). Understanding the constraints that regulate the distribution of ROs across different organisms is fundamental for quantifying the degree of replication errors and their downstream consequences. Using a simple probabilistic model, we generate a set of predictions on the extreme sensitivity of ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1998
ISSN: 1460-2075
DOI: 10.1093/emboj/17.22.6427